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本文采用琼脂凝胶电泳法测定62例急性心肌梗塞(AMI)和19例心绞痛(AP)病人血清肌酸激酶MM同功酶(CK-MM)亚带MM_3/MM_1比值及肌酸激酶同功酶(CK-MB)和肌红蛋白(Mb)的改变,并比较它们在AMI中的诊断价值。结果表明:AMI组首次血清的MM_3/MM_1比值为1.85±2.01(x±s),AP组为0.24±0.14,二者比较差异非常显著(P<0.01)。首次血清和系列测定对AMI的早期诊断价值高于CK-MB和Mb。本组结果亦表明MM_3/MM_1比值的累积阳性率于梗塞发生后6小时达100％。提示血清CK-MM亚带MM_3/MM_1比值异常是AMI早期诊断中敏感而特异的酶学诊断指示。
In this paper, the ratio of MM_3 / MM_1 in serum creatine kinase MM isozymes (CK-MM) and creatine kinase isoenzyme in 62 patients with acute myocardial infarction (AMI) and 19 patients with angina pectoris (AP) were determined by agarose gel electrophoresis (CK-MB) and myoglobin (Mb), and to compare their diagnostic value in AMI. The results showed that the MM3 / MM1 ratio of the first serum of AMI group was 1.85 ± 2.01 (x ± s) and that of AP group was 0.24 ± 0.14, the difference was significant (P <0.01). The first serum and series of tests have a higher early diagnostic value for AMI than CK-MB and Mb. The results of this group also showed that the cumulative positive rate of MM_3 / MM_1 was 100% 6 hours after infarction. It is suggested that the abnormal MM_3 / MM_1 ratio in serum CK-MM subbands is a sensitive and specific diagnostic indicator for early diagnosis of AMI.