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为评定杀精药壬苯醇醚Nonoxynol-9(NP-9)的阴道刺激性及是否可用于临床,选用WHO推荐的Eckstein兔法对中国药科大学药厂(药大)和美国Ortho药厂(Ortho)生产的NP-9在平行条件下进行检测。 药品和器械(1)中国药科大学生产的外用避孕膜,批号870822,每张含NP-950mg。预先将不同剂量的药膜卷成长约
To assess the vaginal irritation of nonoxynol-9 (NP-9), a spermicide nonoxynol-9, and to determine whether it can be used in clinical practice, Eckstein rabbit recommended by WHO was used to evaluate the vaginal irritation of China Pharmaceutical University (CRP) and Ortho Pharmaceutical NP-9 produced by Ortho was tested under parallel conditions. Drugs and Apparatus (1) Topical contraceptive film produced by China Pharmaceutical University, lot number 870822, each containing NP-950mg. Pre-different doses of the film into a roll about