近年来,随着细胞培养技术的发展,人们越来越重视炎症细胞和炎症介质在肾小球肾炎发病中的作用。自70年代起人们就开始探讨循环免疫复合物或原位免疫复合物在肾炎发生蛋白尿中的作用。现进一步认识到,肾小球的损伤可能与下列因素有关:(1)由于激活血小板和凝血因子造成毛细血管闭塞,内皮细胞、系膜细胞增生和新月体形成;(2)多形核嗜中性白细胞、巨噬细胞等炎性细胞所分泌 In recent years, with the development of cell culture technology, people pay more and more attention to the role of inflammatory cells and inflammatory mediators in the pathogenesis of glomerulonephritis. Since the 1970s, people began to explore the role of circulating immune complexes or in situ immune complexes in nephritis-induced proteinuria. It is further recognized that glomerular damage may be related to the following: (1) capillary occlusion, endothelial cells, mesangial cell proliferation and crescent formation due to activation of platelets and clotting factors; (2) polymorphism Neutrophils, macrophages and other inflammatory cells secreted