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目的 探讨脑电图高峰节律紊乱 (Hypsarrhthmia)的临床意义及其变异类型。 方法 结合临床分析 181例有高峰节律紊乱病人的脑电图。结果 181例表现高峰节律紊乱的患者中婴儿痉挛 (West综合征 ) 10 9例(6 0 % ) ,非West综合征癫痫 6 0例 (33% ) ,没有惊厥病史者 11例 (6 % ) ,包括精神运动发育迟缓 7例 (4 % ) ,Rett综合征 3例 (2 % )。非West综合征癫痫 6 0例患者中 ,继发性癫痫为主 ,有明显脑器质性损害者 37例 (6 2 % ) ,伴有精神运动发育落后者 2 1例 (35 % )。高峰节律紊乱变异类型最常见者为爆发抑制 ,占 10 0例 (5 5 % ) ,而典型高峰节律紊乱只见于 74例 (4 1% ) ,其它较常见的变异类型为周期性 5 4例 (30 % ) ,不对称型 2 5例 (14% ) ,同步化 2 2例(12 % )。随睡眠加深 ,由典型高峰节律紊乱变为爆发抑制者 43例 (2 4% )。结论 认识HYPS的临床意义及其变异类型有利于提高有关疾病的脑电图及临床诊断水平。
Objective To investigate the clinical significance and variation types of Hypsarrhthmia (EEG). Methods 181 cases of patients with peak rhythm disorders were analyzed by EEG. Results Among 181 patients with peak rhythm disorder, 109 (60%) were infantile spasms (60%), 60 (33%) were non-West syndrome seizures, 11 (6%) were without convulsions, Including mental retardation in 7 cases (4%), Rett syndrome in 3 cases (2%). Non-West syndrome 60 cases of epilepsy, secondary epilepsy, 37 cases of obvious brain organic damage (62%), with mental retardation in 21 cases (35%). The most common type of variation in peak rhythm disorders was outbreak suppression, accounting for 10 0% (5 5%), whereas typical peak rhythm disorders were found in 74 cases (41%) and other more common types of variation were cyclically 54 ( 30%), asymptomatic 25 cases (14%), synchronization of 22 cases (12%). With the deepening of sleep, from the typical peak rhythm disorders into outbreak suppression in 43 cases (24%). Conclusion Understanding the clinical significance of HYPS and its type of mutation is helpful to improve the EEG and clinical diagnosis of the disease.