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目的 :探讨Ⅰ型胶原交联羧基末端肽 (ICTP)和Ⅰ型前胶原氨基端前肽 (PINP)在骨转移Ca中的临床价值。方法 :血清ICTP、PINP采用放免法检测。 1 1 5例骨转移癌患者分三组进行研究即 :A组 :骨转移灶 <6个 4 7例 ;B组 :骨转移灶 6 2 0个 4 2例 ;C组 :骨转移灶 >2 0或超级显像 2 6例。结果 :骨转移癌患者血清ICTP、PINP较对照组明显升高 (p <0 0 1 ) ;A、B、C三组血清ICTP、PING逐步升高 ,组与组之间差异显著 ;血清ICTP、PING与骨转移数目的相关性好 ,相关系数分别为 0 6 8和 0 5 2 (p均 <0 0 1 ) ;35例患者经治疗后 ,血清ICTP和PINP不同程度地下降 (p分别 <0 0 1、0 0 5 )。 结论 :血清ICTP与PINP的检测都能反映骨转移患者的病情和疗效的变化 ,以血清ICTP的检测临床价值高
Objective: To investigate the clinical value of type Ⅰ collagen cross-linked carboxyl terminal peptide (ICTP) and type Ⅰ procollagen amino terminal propeptide (PINP) in bone metastases. Methods: Serum ICTP and PINP were detected by radioimmunoassay. A total of 115 patients with metastatic bone cancer were divided into three groups: group A: 47 cases of bone metastasis <6 cases; group B: 62 cases of bone metastases; 42 cases; Group C: bone metastases> 2 0 or super-imaging 26 cases. Results: Serum ICTP and PINP in patients with bone metastasis were significantly higher than those in control group (p <0.01); serum ICTP and PING increased gradually in groups A, B and C, with significant difference between groups; serum ICTP, The correlation between PING and the number of bone metastases was good, with correlation coefficients of 0 6 8 and 0 5 2 respectively (p <0.01). After treatment, serum ICTP and PINP decreased in all 35 patients (p <0 0 1,0 0 5). Conclusion: The detection of serum ICTP and PINP can all reflect the changes of the disease and the curative effect of patients with bone metastasis. The detection of serum ICTP is of high clinical value