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目的研究汉族冠心病患者血浆中组织因子活性(aTF)、活化凝血因子VII(FVIIa)和凝血因子VII抗原(FVII:Ag)水平并探讨其与冠脉病变支数之间的关系。方法aTF采用发色底物法,FVIIa和FVII:Ag采用ELISA法。结果与对照组相比,冠心病患者血浆中aTF(P<0.05)、FVIIa(P<0.01)及FVII:Ag(P<0.05)水平均显著升高;急性冠状动脉综合征(ACS)患者中aTF高于稳定型心绞痛(SAP)组(P<0.05)和对照组(P<0.01),后两者之间无显著差异;ACS和SAP患者之间血浆中FVIIa水平无显著差异,但均高于对照组;ACS组中FVII:Ag水平明显高于对照组。在不同冠脉病变支数的患者之间,aTF、FVIIa及FVII:Ag水平没有差异。结论SAP和ACS患者均可出现外源性凝血途径的激活,血浆中aTF增强可能预示了急性冠脉事件的发生;FVIIa可能可以作为冠心病的早期分子标志物;冠脉病变支数可能不能反映凝血激活的程度。
Objective To investigate the relationship between plasma aTF, FVIIa and FVII: Ag in patients with coronary heart disease (CHD) and to investigate the relationship between them and the number of coronary lesions. Method aTF using chromogenic substrate method, FVIIa and FVII: Ag using ELISA method. Results Compared with the control group, the levels of aTF (P <0.05), FVIIa (P <0.01) and FVII: Ag (P <0.05) in patients with coronary heart disease were significantly increased The level of aTF in patients with ACS was significantly higher than that in patients with SAP (P <0.05) and control group (P <0.01), but there was no significant difference between the two groups In control group, the level of FVII: Ag in ACS group was significantly higher than that in control group. There was no difference in aTF, FVIIa, and FVII: Ag levels between patients with different coronary lesion counts. Conclusions Exogenous coagulation pathway activation may occur in both SAP and ACS patients. The increase of aTF in plasma may predict the occurrence of acute coronary events. FVIIa may be an early molecular marker of coronary heart disease. The number of coronary lesions may not reflect The degree of coagulation activation.