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目的:探讨血γ干扰素诱导蛋白10(IP-10)水平检测对活动性肺结核诊断的临床价值。方法:选取活动性肺结核患者81例(包括菌阳肺结核28例、菌阴肺结核53例)、非结核肺部疾病22例、健康志愿者12例,予检测血IP-10、血4项结核抗体水平及行血结核感染T细胞斑点试验(T-SPOT),并进行统计分析。结果:活动性肺结核组的IP-10水平[(200.74±150.71)ng·L~(-1)]高于非结核肺部疾病组[(116.99±99.14)ng·L~(-1)]及健康组[(48.12±31.43)ng·L~(-1)],差异均有统计学意义(均P<0.05);IP-10水平检测活动性肺结核的敏感性和特异性(90.1%和91.7%)均高于血4项结核抗体(70.4%和75%)及血T-SPOT(46.9%和75%)。结论:IP-10水平在活动性肺结核中显著升高,可作为活动性肺结核诊断的辅助指标。
Objective: To investigate the clinical value of serum interferon-inducible protein 10 (IP-10) in the diagnosis of active pulmonary tuberculosis. Methods: 81 cases of active pulmonary tuberculosis (including 28 cases of bacillary positive pulmonary tuberculosis, 53 cases of bacteriar negative pulmonary tuberculosis), 22 cases of non-tuberculosis pulmonary disease, 12 healthy volunteers were selected for detection of blood IP-10, blood 4 tuberculosis antibody T-cell spot test (T-SPOT) of blood-borne TB infection and statistical analysis. Results: IP-10 level in active tuberculosis group was significantly higher than that in non-tuberculosis pulmonary disease group ([(200.74 ± 150.71) ng · L -1] and [116.99 ± 99.14 ng · L -1] (48.12 ± 31.43 ng · L -1) in healthy group (all P <0.05). The sensitivity and specificity of IP-10 in detecting active tuberculosis (90.1% and 91.7 %) Were higher than those of 4 TB antibodies (70.4% and 75%) and T-SPOT (46.9% and 75%). Conclusion: The level of IP-10 is significantly increased in active pulmonary tuberculosis, which can be used as an auxiliary index for the diagnosis of active pulmonary tuberculosis.