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ＡＰＣ基因是近年来发现的定位于人染色体 5ｑ2 1的抑癌基因 ,目前已被发现涉及多种肿瘤的形成。我们采用聚合酶链反应 限制性片段长度多态性 (ＰＣＲ ＲＦＬＰ)方法检测了急性白血病患者 48例的ＡＰＣ基因杂合性缺失 (ｌｏｓｓｏｆｈｅｔｅｒｏｚｙｇｏｓｉ ｔｙ ,ＬＯＨ) ,?
APC gene is a tumor suppressor gene located in human chromosome 5q21 recently discovered and has been found to be involved in the formation of a variety of tumors. We used polymerase chain reaction restriction fragment length polymorphism (PCR RFLP) to detect loss of heterozygosity (AP) loss in 48 patients with acute leukemia (loss of heteozygosi ty, LOH),?