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本文研究了国产利福喷丁对29种331株非分枝杆菌病原菌的体外抗菌活性以及它与19种抗生素对30株金葡菌、10株凝固酶阴性葡萄球菌、10株粪链球菌和10株非肠球菌的体外联合抗菌作用。结果表明利福喷丁对8种革蓝氏阳性球菌均具较强抗菌活性,0.5mg/L即可抑制90％的金葡萄(包括耐苯唑青霉素的金葡菌)和凝固酶阴性葡萄球菌的生长,4mg/L可抑制90％的粪链球菌和非肠球菌生长,但略逊于利福定和利福平。利福喷丁与青霉素G、苯唑青霉素、氨苄青霉素、氧哌嗪青霉素,头孢噻啶、头孢唑啉、头孢孟多、头孢噻肟、头孢哌酮、头孢三嗪、Ceftazidime、庆大霉素、丁胺卡那霉素、氯霉素和氟哌酸联合呈明显协同作用,与红霉素、洁霉素、万古霉素和强力霉素联合主要是无关作用,且在少量菌株中表现出拮抗作用。
In this paper, we studied the in vitro antibacterial activity of domestic rifabutin against 29 non-mycobacterial pathogens of 331 strains and its relationship with 19 antibiotics against 30 Staphylococcus aureus, 10 coagulase-negative Staphylococcus, 10 Streptococcus faecalis and 10 In vitro combined antibacterial activity of non-enterococci strains. The results showed that rifapentin had strong antibacterial activity against 8 kinds of gram-positive cocci, 0.5mg / L could inhibit 90% of gold grape (including oxacillin-resistant S. aureus) and coagulase-negative staphylococcus 4 mg / L inhibited the growth of 90% of fecal streptococci and non-enterococci, but slightly inferior to rifadin and rifampicin. Rifapentine and penicillin G, oxacillin, ampicillin, piperacillin penicillin, cefotaxime, cefazolin, cefmetazole, cefotaxime, cefoperazone, cefotaxime, ceftazidime, gentamicin , Amikacin, chloramphenicol and norfloxacin showed a significant synergistic effect with erythromycin, lincomycin, vancomycin and doxycycline combined mainly irrelevant role, and in a small number of strains showed Antagonism.