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第二代钙通道拮抗剂尼瓦地平属于1,4-二氢吡啶衍生物,它具有电压依赖性慢钙通道阻滞作用.它有很强的血管扩张能力,可降低动脉血压,扩张冠状动脉,改善心肌缺血,增加缺血区的心内膜下灌流量;还有扩张肾血管,增加肾有效血流量和利尿的双重作用.它对心肌组织和传导系统的影响较小.此外,尚有抗动脉粥样硬化的作用.与其他钙通道拮抗剂相比,尼瓦地平对光稳定性好,作用强,用量小,吸收佳,副作用少,它可能成为防治心绞痛、心肌缺血性心脏病、脑血管痉挛和高血压等疾病有希望的新药.
The second-generation calcium channel antagonist, nivodipine, is a 1,4-dihydropyridine derivative that has a voltage-dependent slow calcium channel blockade and has a strong vasodilator capacity that reduces arterial blood pressure and dilates coronary arteries , Improve myocardial ischemia, increase subretinal perfusion in the ischemic area; there are dual effects of dilating renal vessels, increasing renal effective blood flow and diuresis, which has little effect on myocardial tissue and conduction system.In addition, Anti-atherosclerotic effect.Compared with other calcium channel antagonists, niludipine is good for light stability, strong effect, small dosage, good absorption and few side effects, and it may become an anti-angina and myocardial ischemic heart Disease, cerebral vasospasm and hypertension and other diseases promising new drugs.