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Ⅰ型和Ⅱ型单纯性疱疹病毒(HSV_1,HSV_2)可引起皮肤粘膜感染,病变经常出现于口周围和生殖器部位.三唑核苷(Ribavirin)是一种抗病毒药物,属于合成的核苷类似物.目前它仍处于试验阶段,其抗病毒机理尚不清楚,体外显示有“抑制病毒”的作用.一般情况下副作用轻微,偶见正色性-正常红细胞性贫血.本研究对三唑核苷进行了临床和实验室评价.评价分为:(1)三唑核苷对复发性单纯疱疹的疗效;(2)药物治疗后12个月内疱疹复发次数;(3)受试者对药物的耐受性;(4)药物对血液学、免疫学参数以及肝肾功能的影响.研究对象为38名患有复发性单纯疱疹的成年病人,接受口服三唑核苷治疗(800～1600mg/d,共8天),同时以安慰剂作对照,采用随
Skin herpes simplex virus type 1 and type 2 (HSV_1, HSV_2) can cause skin and mucous membrane infections, lesions often appear in the mouth and genital area. Ribavirin is an antiviral drug, which belongs to the synthetic nucleoside analogues It is still in the experimental stage, the anti-virus mechanism is not clear, in vitro showed The effect of triadimefon Nucleosides were evaluated clinically and in laboratory, and the evaluation was divided into: (1) the efficacy of triadimenosyl on recurrent herpes simplex; (2) the number of herpes relapses within 12 months after drug treatment; (3) (4) The effects of drugs on hematology, immunological parameters and liver and kidney function.Methods 38 adult patients with recurrent herpes simplex were treated with oral ribavirin (800 ~ 1600mg / d, a total of 8 days), while taking placebo as control, with