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目的通过回顾性分析新型布尼亚病毒感染患者继发细菌或真菌感染,探索高载量新型布尼亚病毒感染与预后相关性,为临床诊治危重症患者提供参考依据。方法对医院2013年9月-2015年9月收治70例发热伴血小板减少综合征病例资料进行回顾性分析,比较病程中培养结果和布尼亚核酸检测结果与患者预后相关性,数据采用SPSS 20.0软件进行统计分析。结果患者以中老年农民为主,多在5~7月份发病,17.39%患者有明确蜱叮咬史;共分离10株病原菌,以曲霉菌为主,共3株占30.00%;23例布尼亚病毒核酸阳性,其中重症患者死亡5例,痊愈患者18例。结论出现感染性休克的患者预后差,病死率高;在诊疗过程中,宜采取有效抗感染治疗方案和对症支持治疗,尤其对于重症患者需加强实验室指标的监测和病情监护。
OBJECTIVE: To provide a reference for clinical diagnosis and treatment of critically ill patients by retrospectively analyzing secondary bacterial or fungal infections in patients with new Bunyan virus infection and exploring the correlation between the high-load new Bunyavirus infection and prognosis. Methods The data of 70 cases of fever with thrombocytopenia admitted from September 2013 to September 2015 in our hospital were retrospectively analyzed. The correlation between the results of culture and the results of Bunia and the prognosis of patients were compared. The data were analyzed by SPSS 20.0 software conduct statistical analysis. Results The patients were mainly middle-aged and elderly peasants, mostly in the period of May-July. 17.39% of the patients had a clear history of tick bites; 10 pathogens were isolated, of which 3 were aspergillus, accounting for 30.00%; 23 cases of Bunia The virus nucleic acid positive, including 5 cases of critically ill patients, 18 patients cured. Conclusions Patients with septic shock have poor prognosis and high mortality rate. In the course of diagnosis and treatment, effective anti-infective therapy and symptomatic and supportive care should be taken, especially for critically ill patients, monitoring and monitoring of laboratory indicators should be strengthened.