胰岛素一直是治疗糖尿病尤其是胰岛素依赖型(I型)糖尿病的首选药物之一。目前,胰岛素在临床上主要是通过皮下注射途径给药,每日3-4次,长期用药,病人痛苦不堪,而且用药后也可能出现炎症、硬结、过敏等副作用以及耐药性[1]。因此,胰岛素新的给药系统的研究已成为近年来药剂学领 Insulin has long been one of the drug of choice for the treatment of diabetes, especially insulin-dependent (type I) diabetes. At present, insulin is administered clinically mainly through the subcutaneous injection route, 3-4 times a day, long-term medication, and the patient is suffering. Moreover, side effects such as inflammation, induration, allergy and drug resistance may also occur after treatment. Therefore, the research of insulin new drug delivery system has become the leader of pharmacy in recent years