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合成了一种可在结肠部位被特异酶解的两亲性嵌段高分子,由聚丙交酯(PLA)疏水嵌段和聚乙二醇(PEG)亲水嵌段组成,两者通过5,5′-偶氮二水杨酸(OLZ)偶联,其中的偶氮键可被结肠部位的偶氮还原酶特异酶解.利用FTIR、NMR和GPC等方法表征了共聚物的结构,并通过透射电镜(TEM)和动态光散射(DLS)等方法研究了该高分子载体在水溶液中的组装行为.结果表明MPEG-OLZ-b-PLA可在水介质中形成尺寸在30nm左右的球形胶束,并在大鼠全盲肠提取液中被特异性酶解。
A kind of amphipathic block polymer which can be specifically hydrolyzed in the colon was synthesized. It was composed of hydrophobic blocks of polylactide (PLA) and hydrophilic blocks of polyethylene glycol (PEG) 5’-azobisalicylic acid (OLZ), in which the azo bond can be enzymatically digested by azo-reductase in the colon site.The structure of the copolymer was characterized by FTIR, NMR and GPC, Transmission electron microscopy (TEM) and dynamic light scattering (DLS) were employed to investigate the assembly behavior of the polymer carrier in aqueous solution. The results showed that MPEG-OLZ-b-PLA could form spherical micelles , And was specifically digested in rat cecal extract.