1959年AVeuy和Mead首次报导临床上新生儿肺透明膜病是由肺表面活化物质缺乏和肺功能异常干扰肺泡Ⅱ型细胞上皮的成熟合成而产生的。本症是一种初发病并可由继发因素加重,是早产儿和新生儿发病率和死亡率较高的原因之一。Gluck以薄层层析法测定卵磷脂与鞘磷脂比值(L/S)来预测胎儿肺成熟度,但对妊娠合并糖尿病的羊水标本L/S比值有假象出现,为能更精确地预测肺成熟 In 1959, AVeuy and Mead for the first time reported that clinical neonatal hyaline membrane disease is caused by the lack of pulmonary surfactant and pulmonary dysfunction interfering with the mature synthesis of alveolar type Ⅱ cell epithelium. This disease is a primary disease and may be caused by secondary factors, is one of the reasons for the higher morbidity and mortality in premature children and newborns. Gluck thin layer chromatography method to determine the ratio of lecithin and sphingomyelin (L / S) to predict fetal lung maturity, but the amniotic fluid specimens with gestational diabetes mellitus L / S ratio false impression appears to be more accurate prediction of lung maturation