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肾细胞癌是泌尿系统常见的肿瘤之一，占肾癌病例的90%，其中又以透明细胞亚型最为常见。由于肾细胞癌对常规抗癌治疗的反应较差，其在癌症初期即可出现转移。肾细胞癌的高度转移性决定了对其进行早期诊断的必要性和重要性。尽管临床对肾细胞癌已投入大量研究精力，但其机制仍不明确。最近有研究表明，斑点型POZ蛋白(SPOP)可以以癌症类型特异性的方式发挥生物学功能。本文基于最新研究结果综述了SPOP在肾细胞癌中的研究现状及展望。“,”Renal cell carcinoma is one of the most common urinary tract cancers, accounting for 90% of renal cancer cases, and the clear cell renal cell carcinoma is its most common subtype. Because of poor response to conventional anti-cancer treatment, metastasis may occur in the early stage of renal cell carcinoma. The high degree of metastasis of renal cell carcinoma determines the necessity and importance of early diagnosis. Although a lot of researches about renal cell carcinoma have been carried out, its underlying mechanisms still remain unclear. Recent studies have shown that spot-type POZ protein (SPOP) can perform biological functions in a cancer type-specific way. Based on the latest findings, this article reviewed the current research status and prospectives of SPOP in renal cancer cells.