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本文复习了81例伴有恶性肿瘤、胶原性血管病及同种异体器移植患者的弓浆虫病,其临床表现虽很有差别,但与弥漫性脑病、脑膜脑炎或大脑占位性损害的各种主要神经综合征则颇相一致。不少病例合并DNA病毒感染。多数患者的弓浆虫病的诊断是在尸检时才作出的。具有诊断意义的淋巴结或脑组织活检和血清学试验,在这些患者生前都做得很少。81例中20例接受过抗弓浆虫药物治疗(乙胺嘧啶和磺胺),16例(80％)的临床症状显著好转或完全缓解。在有免疫抑制的宿主中,播散性弓浆虫病的发生显然是由于细胞免疫缺陷所致,因为免疫缺陷可使隐性感染进一步加重。实验动物宿主获得佐药后可
This review of 81 cases of toxoplasmosis associated with malignant tumors, collagenous vascular disease and allograft transplantation patients, although the clinical manifestations are very different, but with diffuse encephalopathy, meningoencephalitis or cerebrovascular injury The various major neurological syndrome is quite consistent. Many cases of DNA virus infection. Toxoplasmosis in most patients is diagnosed at necropsy. Diagnostic lymph nodes or brain biopsies and serological tests are rare in these patients. Twenty of 81 patients received anti-methicillin drug therapy (pyrimethamine and sulfonamides) and 16 (80%) had clinically significant or complete remission. In immunocompromised hosts, the occurrence of disseminated toxoplasmosis is clearly due to cellular immunodeficiency, which can aggravate the latent infection. Experimental animal host can be obtained after adjuvant