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据以往报告在掌蹠脓疱病(PPP)以及其它一些皮肤病中,经体外试验发现其嗜中性白细胞的吞噬能力具有缺陷。近来Brandt证实氯苯吩嗪(Clofazimine)可能增强嗜中性白细胞的吞噬活性。作者对27例(男性8例,女性19例)PPP病人口服氯苯吩嗪治疗的临床效果及其对吞噬作用的影响进行了研究,观察时间均在一年以上。这些病人的年龄为27～63岁,平均为45岁。病期均在3年以上,至少在氯苯吩嗪治疗前的一年来病情处于静止期,即既无自然缓解也不因治疗而缓解。其中8例有
It has been reported in the past in palmoplantar impetigo (PPP) and other skin diseases, in vitro tests found that its neutrophil phagocytosis has defects. Recently Brandt confirmed that clofazimine may enhance phagocytic activity of neutrophils. The authors studied the clinical effect of oral chlorophenazine in 27 patients (8 males and 19 females) and their effects on phagocytosis. The observation time was more than one year. The age of these patients is 27 to 63 years old, with an average of 45 years. The duration of illness was more than 3 years, at least one year before clopidophylline treatment, the disease was in quiescence, that is neither spontaneous nor alleviated by treatment. Of which 8 cases have