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益肤酰胺是近来由沈阳药学院与大庆市第一医院发现的一种治疗痤疮新药,疗效确切。它是复方乙酰水杨酸片灼烧后的产物,经分离和光谱鉴定证明为N-(4-乙氧苯基)-2-羟基苯酰胺,结构如(Ⅰ),合成方法已有报道。为了验证其化学结构和探讨合成方法,我们进行了化学合成。
Benefit amide is recently discovered by Shenyang Pharmaceutical College and Daqing First Hospital acne new drugs, the exact effect. It is the product of the compound acetylsalicylic acid tablets after burning, which is proved to be N- (4-ethoxyphenyl) -2-hydroxybenzamide after separation and spectral identification. The structure is as shown in (I) and the synthesis method has been reported. In order to verify its chemical structure and to explore the synthesis method, we conducted a chemical synthesis.