青霉素自1940年间世以来,由于抗菌谱较广泛,同时作用强而毒性低,因而很快的被临床各科应用了。以后应用日渐广泛与普及,随着青霉素的应用日广,其不良反应的发病率也逐渐增多起来,据王氏报告不良反应的发病率已由2％增至15％,其中过敏性休克最为严重,根据1952年后初步统计,国内严重致死已报告者有8例,而西安地区由 Since1940s, penicillin has been widely used in clinical departments due to its broad antimicrobial spectrum, strong and low toxicity. With the increasing application of penicillin, the incidence of adverse reactions is gradually increasing. According to Wang’s report, the incidence of adverse reactions has increased from 2% to 15%, of which the most severe is atypical shock , According to preliminary statistics after 1952, there were 8 cases of serious domestic fatalities reported in Xi’an