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本文作者分别研究了代表不同溶解度、不同筛号的药物,如碳酸氢钠、乳糖及三矽酸镁的颗粒压制成片剂时对崩解时间及脱顶的关系。碳酸氢钠及乳糖各用10%阿拉伯胶浆、三矽酸镁用50%糖浆一醇的混合物作粘合剂。方法:将三种成分及玉米淀粉等分别置烘箱中以120°F于燥三天后,称取85份与淀粉15份相混合,通过磨粉机及200号筛,再在混合机中用上述粘合剂粘合,湿料通过装有6号筛网的颗粒机,在120°F干燥—星期,干燥物料重新过筛,收集各号颗粒,分别加1%硬
The authors studied the relationship between disintegration time and decapitation when granulated tablets of different solubilities and different mesh sizes, such as sodium bicarbonate, lactose and magnesium trisilicate, were compressed into tablets. Sodium bicarbonate and lactose each with 10% gum arabic, magnesium trisilicate with 50% syrup-alcohol mixture as a binder. Methods: The three ingredients and corn starch, etc. were placed in the oven at 120 ° F in the dry three days, weighed 85 and 15 parts of starch are mixed, through the mill and sieve 200, and then in the mixer with the above The adhesive was bonded and the wetted material was passed through a pelletizer equipped with a No. 6 mesh screen and dried at 120 ° F for a week. The dried material was rescreened and the particles of each number were collected, respectively 1% hard