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目的探讨染色体9p21基因单核苷酸多态性(single nucleotide polymorphism,SNP)与新疆维吾尔族人群冠心病(coronary heart disease,CHD)的关系。方法选择172例冠状动脉造影证实的CHD患者(冠心病组)和147例对照组作为研究对象,应用LDR-PCR技术对rs1333049位点进行SNP分型及分析。结果冠心病组和对照组rs1333049CC基因型频率分别为39.0%和20.4%,C等位基因频率分别为59.9%和48.6%;两组比较差异有统计学意义(P<0.05)。调整相关因素后,多因素Logistic回归分析结果提示rs1333049CC基因型仍是CHD的危险基因型,OR值为2.40,95%CI(1.25～4.61)。结论 rs1333049多态性与维吾尔族人群CHD易感性相关。
Objective To investigate the relationship between chromosome 9p21 single nucleotide polymorphism (SNP) and coronary heart disease (CHD) in Xinjiang Uygur population. Methods One hundred and seventy-two CHD patients (coronary heart disease group) and 147 control subjects confirmed by coronary angiography were selected as study objects. SNP typing and analysis of rs1333049 loci were performed by LDR-PCR. Results The genotypes of rs1333049CC in CHD group and control group were 39.0% and 20.4%, respectively. The frequency of C allele was 59.9% and 48.6% respectively. There was significant difference between the two groups (P <0.05). After adjustment for the relevant factors, multivariate Logistic regression analysis suggested that rs1333049CC genotype was still a risk genotype of CHD with OR of 2.40 and 95% CI (1.25-4.61). Conclusion rs1333049 polymorphism is associated with CHD susceptibility in Uygur population.