人们已知道口服非甾体抗炎药物可引起急性肾功能衰竭的并发症1,2 。相比较而言 ,通常认为局部应用这类药物是安全的 ,因其很少经皮肤吸收 (5 %～ 8% ) 3。我们报道一例局部应用酮洛芬 (ｋｅｔｏｐｒｏｆｅｎ)导致急性肾功能衰竭的病例。一位 6 2岁的土耳其妇女患有多囊肾 ,慢性 It is known that oral NSAIDs can cause complications of acute renal failure 1, 2. In contrast, topical application of these drugs is generally considered safe because it is less absorbed through the skin (5% to 8%) 3. We report a case of topical ketoprofen-induced acute renal failure. A 62-year-old Turkish woman has polycystic kidney disease, chronic