论文部分内容阅读
据报道乙型肝炎疫苗皮内接种经济、有效。作者把173名18～22岁女学生随机分成7组,接种重组乙型肝炎疫苗。组1～组6为皮内接种组,每次2或4μg,不同间隔接种3～4次。接种程序分别为:组1为0、1、4周(0周为2μg,1、4周各为4μg);组2、组3为0、2、4周(组20周为2μg,2、4周各为4μg;组3均为4μg);组4为0、2、4、6周(每次均为2μg);组5为0、2、4周、6月(每次均为2μg);组6为0、4周、6月(每次均为2μg);组7(对照组)为0、4周、6月,每次均为肌肉注射10μg。4、8周及4、7个月全部对象采集血标本,12个月时仅对组4、组5和组7采血。以ELISA测定,抗-HBs>2IU/L为阳性。
Hepatitis B vaccine is reportedly inoculated intradermally economically and effectively. The author of 173 18 to 22-year-old female students were randomly divided into 7 groups, vaccination of recombinant hepatitis B vaccine. Group 1 ~ group 6 intradermal vaccination group, each 2 or 4μg, vaccinated at different intervals 3 to 4 times. Inoculation procedures were: group 1 was 0, 1, 4 weeks (0 weeks 2μg, 1, 4 weeks each 4μg); group 2, group 3 0,2,4 weeks (20 weeks for the group of 2μg, 4 μg each for 4 weeks; 4 μg for group 3); group 4 for 0, 2, 4, and 6 weeks (each 2 μg); group 5 for 0, 2, 4 weeks and 6 months ); Group 6 was 0, 4 weeks, 6 months (each 2μg); Group 7 (control group) was 0, 4 weeks, 6 months, each injection of 10μg intramuscularly. Blood samples were collected from all subjects at 4, 8, and 4 and 7 months, and blood was collected only from group 4, group 5 and group 7 at 12 months. Anti-HBs> 2IU / L was positive by ELISA.