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测定66例T2DM患者及62例年龄、BMI相匹配的健康对照者的BMD、血清TNF、骨钙素(BGP)、碱性磷酸酶(AKP)、血钙(Ca)、磷(P)、尿Ca/Cr、尿羟脯氨酸(HOP)/CrI、型胶原羧基末端肽(CTX)/Cr水平,2组进行比较。结果 T2DM患者较对照组的BMD显著降低,血清BGP水平明显低于对照组(P<0 01);TNF、尿HOP、显著高于对照组(P<0.01),TNF与BMD呈显著负相关。结论男性2TDM患者易并发OP,其原因与TNF水平升高有一定关系。
Sixty-six patients with T2DM and 62 age-matched healthy controls with BMI were measured for BMD, serum TNF, BGP, AKP, Ca, P, Ca / Cr, HOP / CrI, CTX / Cr levels were compared between the two groups. Results Compared with the control group, the BMD of T2DM patients was significantly lower than that of the control group (P <0.01). The levels of BGP and BGP in serum were significantly lower than those in the control group (P <0.01). Conclusions Male patients with 2TDM are prone to complicated with OP, the reason is related to the increase of TNF level.