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6,6-二霉菌酸海藻糖(索因子)〔Trehalose-6,6-dimycolate(Cord-factor)〕是从分枝杆菌中提取的一种糖酯,静脉注射1-5微克后可诱发小鼠肺部肉芽肿反应,由索因子所引起的结节的细胞组成与活的卡介苗所引起的没有区别,两者的肉芽肿都由上皮细胞、巨噬细胞和淋巴细胞组成。小鼠脚蹼注射索因子,在引流淋巴结(draining lymphnodes)引起的组织学变化亦与注射活的卡介苗相似,两者都可形成肉芽肿,在副皮质层的淋巴样组织有明显增生,并有巨噬细胞聚集。由于在肝、脾和肺等的器官中证明没有细胞反
Trehalose-6,6-dimycolate (Cord-factor), a sugar ester extracted from mycobacteria, can induce small Rat lung granuloma reaction caused by cord factor caused by nodules and live BCG caused no difference between the two granulomas are composed of epithelial cells, macrophages and lymphocytes. Mouse fins injected with cofactor and histological changes induced by draining lymphnodes are also similar to those injected with live BCG, both of which can form granulomas with significant hyperplasia of the lymphoid tissue in the paracortex and a giant Macrophage aggregation. Since there is no evidence of cell resistance in organs such as liver, spleen and lung