抗疟药的作用方式和药物抗性的基础研究1967年以来,对于阐明抗疟药的作用方式及探讨疟原虫发生抗药性的状况进行了大量的研究工作。1.疟原虫的结构和功能电子显微镜的应用,进一步阐明了疟原虫红细胞内期和红细胞外期摄食的机制。除伯氏疟原虫(P.berghei)和恶性疟原虫外,对间日疟原虫和三日疟原虫也进行了一些研究。4—氨基喹啉类和阿的平可使疟原虫及其 Basic research on the mode of action and drug resistance of antimalarial drugs Since 1967, a great deal of research has been done on elucidating the mode of action of antimalarial drugs and on the status of resistance to the parasites. 1. The structure and function of Plasmodium Electron microscopy application, further clarify the Plasmodium erythrocytic endoprosthesis and erythrocyte feeding mechanism. In addition to P. berghei and P. falciparum, some studies were also conducted on P. vivax and P. malaria. 4-Amino-quinoline class and the peace of the parasite can make parasite