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设计、合成了咖啡酸苯乙酯及 16个取代肉桂酸苯乙酯化合物 ,并用MTT法或SRB法对其抗肿瘤活性进行了体外筛选。结果显示咖啡酸苯乙酯对HL 6 0、Bel 74 0 2、Hela细胞有较好的抑制活性 ;3,4 二甲氧基肉桂酸苯乙酯对Hela细胞有非常好的抑制活性 ;而 4 丙酮氧基肉桂酸苯乙酯对Bel 74 0 2细胞有非常好的抑制活性。
Design and synthesis of caffeic acid phenethyl ester and 16 substituted phenethyl cinnamate compounds, and their anti-tumor activity were screened by MTT method or SRB method in vitro. The results showed that caffeic acid phenethyl ester had good inhibitory activity on HL 60, Bel 74 0 2 and Hela cells; 3,4-dimethoxycinnamic acid phenethyl ester had a very good inhibitory activity on Hela cells; and 4 Phenoxyacetophenone phenethyl ester has a very good inhibitory activity on Bel 74 02 cells.