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麻风反应是麻风病慢性过程中所发生的急性活跃症状,据认为是由于免疫平衡紊乱引起的一种对麻风杆菌抗原的急性超敏反应。一般分为两型反应:第Ⅰ型是迟发型超敏反应,属于细胞免疫反应,出现皮损红肿、神经肿胀疼痛及四肢浮肿等症状:第Ⅱ型是免疫复合物反应,属于体液免疫反应,出现发热、结节性红斑、神经肿痛、骨关节痛、淋巴结炎、睾丸炎、虹膜睫状体炎、蛋白尿及全身不适等症状。既往国内外多采用锑剂、激素治疗。但锑剂毒性大,激素价贵且副作用多。为了探讨治疗麻风反应的有效方法,于1962年我们试用雷公藤治疗,取得初步疗效。此后,经过六次临床反复验证,获得满意效果,报告如下。
Leprosy is an acute and active symptom of leprosy that occurs during the chronic phase of leprosy and is thought to be an acute hypersensitivity reaction to the leprosy antigen due to a disturbed immune balance. Generally divided into two types of reactions: Type Ⅰ is a delayed type hypersensitivity, cellular immune response, there skin lesions inflamed, painful swelling of the nerves and limbs and other symptoms: Type Ⅱ immune complexes reaction is a humoral immune response, There are fever, nodular erythema, neuralgia, bone and joint pain, lymphadenitis, orchitis, iridocyclitis, proteinuria and general malaise and other symptoms. Previous domestic and international use of antimony agent, hormone therapy. However, antimony agent toxicity, hormones expensive and side effects and more. In order to explore the effective treatment of leprosy response method, in 1962 we tried triptolide treatment, and achieved initial effect. Since then, after six clinical validation repeatedly to obtain satisfactory results, the report is as follows.