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[目的]观察益气活血化痰方联合辛伐他汀片治疗老年颈动脉粥样硬化疗效。[方法]使用随机平行对照方法,将60例门诊及住院患者按随机数字表法分为两组。对照组30例辛伐他汀片,20mg/次,1次/d,口服。治疗组30例益气活血化痰方(黄芪、丹参、桑椹各15g,当归、地龙、石菖蒲、泽泻、川芎各9g,茶树根10g);1剂/d,水煎250mL,早晚口服。西药治疗同对照组。连续治疗168d为1疗程。观测临床症状、血脂水平、颈动脉内中膜厚度(IMT)、血浆纤维蛋白原(FIB)含量、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效0例,有效16例,无效14例,总有效率53.33%。对照组显效0例,有效3例,无效27例,总有效率10.00%。治疗组疗效优于对照组(P<0.05)。血脂水平两组均有改善(P<0.05),治疗组改善优于对照组(P<0.05)。颈动脉内中膜厚度(IMT)两组均有改善(P<0.05),治疗组改善优于对照组(P<0.05)。血浆纤维蛋白原(FIB)含量两组均有改善(P<0.05),治疗组改善优于对照组(P<0.05),治疗组FIB较对照组明显降低。[结论]益气活血化痰方联合辛伐他汀片治疗老年颈动脉粥样硬化效果显著,值得推广。
[Objective] To observe the curative effect of Yiqi Huoxue Huatan Decoction combined with Simvastatin tablets on elderly carotid atherosclerosis. [Methods] Using randomized parallel method, 60 outpatients and inpatients were divided into two groups according to random number table. Control group, 30 cases of simvastatin tablets, 20mg / time, 1 / d, orally. The treatment group 30 cases of Yiqi Huoxue Huatan Fang (Astragalus, Salvia miltiorrhiza each 15g, angelica, earthworm, Shichangpu, Alisma orientalis, Chuanxiong the 9g, tea tree root 10g); 1 / d, decoction 250mL, sooner or later oral . Western medicine treatment with the control group. Continuous treatment of 168d for a course of treatment. Clinical symptoms, blood lipid levels, carotid intima-media thickness (IMT), plasma fibrinogen (FIB) content and adverse reactions were observed. Treatment of a course of treatment to determine the efficacy. [Results] The treatment group markedly effective in 0 cases, effective in 16 cases, ineffective in 14 cases, the total effective rate was 53.33%. In the control group, 0 was markedly effective, 3 effective, 27 ineffective, and the total effective rate was 10.00%. The treatment group was better than the control group (P <0.05). Blood lipid levels were improved in both groups (P <0.05), the treatment group improved better than the control group (P <0.05). The carotid intima - media thickness (IMT) improved in both groups (P <0.05), and the treatment group improved better than the control group (P <0.05). The plasma fibrinogen (FIB) content was improved in both groups (P <0.05), the treatment group improved better than the control group (P <0.05), the FIB group than the control group was significantly lower. [Conclusion] Yiqi Huoxue Huatan Decoction combined with simvastatin tablets is effective in treating carotid atherosclerosis in the elderly and is worth promoting.