从3例患者的外周血单个核细胞中检测到大量人疱疹病毒-6型(HHV-6)基因组的存在,其中2例为淋巴增生性疾病患者,1例患有多发性硬化症。三者均无HHV-6急性或持续性感染的临床表现,经间接免疫荧光检查也未发现此类感染的血清学证据。但从这些患者分离的外周血单个核细胞,经提取DNA后,用HHV-6特异性探针作杂交,发现均有HHV-6基因序列存在,表明外周血单个核细胞是HHV-6潜伏感染的部位之为了获得对潜伏感染时HHV-6基因组在细胞内存在状态的进一步了解,应用脉冲凝胶电泳分析技术,对HHV-6 GS株感染的 Large numbers of human herpesvirus-6 (HHV-6) genomes were detected in peripheral blood mononuclear cells from 3 patients, two of whom were patients with lymphoproliferative disease and one with multiple sclerosis. None of the three had clinical manifestations of acute or persistent HHV-6 infection and no serologic evidence of such infection was found by indirect immunofluorescence. However, peripheral blood mononuclear cells isolated from these patients, after DNA extraction, were hybridized with HHV-6-specific probes and found to have HHV-6 gene sequences, indicating that peripheral blood mononuclear cells are latent HHV-6 infection In order to obtain further understanding of the presence of HHV-6 genome in the cells during latent infection, the HHV-6 GS strain was infected by pulse gel electrophoresis