目的 :了解散发性戊型肝炎(HE)和散发性甲型肝炎(HA)的差别。方法 :对42例HE和70例HA的临床资料进行比较。结果 :HE与HA相比 ,其发病年龄以青壮年为主(P<0 01)血清总胆红素(TBil)、谷丙转氨酶(ALT)、谷草转氨酶(AST)水平高(P<0 01) ,黄疸持续时间及住院时间长(P<0 01) ,重型肝炎发生率高(P<0 05)。结论 :HE未成年患者发病少见 ,肝细胞损害较HA明显 ,预后差 ,在慢性乙型肝炎(CHB)基础上重叠感染戊型肝炎病毒(HEV)是HE重症化的一个重要因 Purpose: To understand the differences between sporadic HE and sporadic HA. Methods: The clinical data of 42 cases of HE and 70 cases of HA were compared. Results Compared with HA, the onset age of HE was mainly young and middle aged (P <0.01), the levels of TBil, ALT and AST were higher (P <0.01) ), Duration of jaundice and length of hospital stay (P <0.01), and high incidence of severe hepatitis (P <0.05). CONCLUSIONS: The incidence of HE in juvenile patients is rare, the damage of hepatocytes is more obvious than that of HA, and the prognosis is poor. Over-infection of hepatitis E virus (HEV) based on chronic hepatitis B (CHB) is an important cause of severe HE