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笔者1994年间试用诺氟沙星治疗疟疾120例,取得了较好的效果。报道如下。临床资料一、病例选择:本组120例,其中男性72例,女性48例,平均年龄32.5岁。所有病例均有疟疾的典型症状且经血涂片查见疟原虫而确诊,其中恶性疟86例,间日疟34例。二、治疗方法:以体重>70kg者用诺氟沙星0.4g,1日3次,<70kg以下者0.3g,1日3次,连用6天。除物理降温及补充液全外,不用其他药物。治疗中每天上下午各测一次体温,每天复查厚血片1次;服药6天后连续3天复查厚血片;服药前及1周后各查肝功、肾功1次。三、结果:24小时内退热,血涂片转阴者8例,48小时内退热、血涂片转阴者55例,72
In 1994, the author trial of norfloxacin 120 cases of malaria, and achieved good results. Reported as follows. Clinical data A case selection: This group of 120 cases, including 72 males and 48 females, with an average age of 32.5 years. In all cases, the typical symptoms of malaria were confirmed by blood smear examination of parasite, including 86 cases of falciparum malaria and 34 cases of vivax malaria. Second, the treatment: weight> 70kg with norfloxacin 0.4g, 1 3 times, <70kg the following 0.3g, 1 3 times, once every 6 days. In addition to physical cooling and replenishment of the whole, no other drugs. Treatment in the morning and afternoon each measured temperature, daily review thick film 1; 6 days after taking medication for 3 consecutive days thick film review; before taking and 1 week after each check liver function, kidney function 1 times. Third, the results: within 24 hours of antipyretic, blood smear negative in 8 cases, within 48 hours of antipyretic, blood smear negative 55 cases, 72