CREST综合征系过去称为CRST综合征的一个亚型,CRST也就是全身性硬化症(PSS)。CREST 是以钙化、Raynaud 现象、食道病变、指尖硬化、毛细血管扩张等为特征的疾患。和通常的PSS比,皮肤硬化仅限于四肢尖端部分,而钙化则即频发又广泛,Raynaud 现象也明显,四肢末端多有溃疡形成,有显著的毛细血管扩张,然而内脏病变少,进行缓慢,预后良好。肺纤维化亦比PSS 轻,合并心脏、肾脏病 The CREST syndrome was a subtype of CRST syndrome in the past, and CRST was systemic sclerosis (PSS). CREST is characterized by calcifications, Raynaud’s phenomenon, esophageal lesions, hardening of the fingers, telangiectasias, and the like. Compared with the usual PSS, skin sclerosis is limited to the tip of the extremities, and calcification is frequent and widespread, Raynaud phenomenon is also obvious, more than the end of the extremities ulceration, significant telangiectasia, however, fewer visceral lesions, slow, The prognosis is good. Pulmonary fibrosis is also lighter than PSS, with heart and kidney disease