CREST综合征为肢端硬皮病的异型。它包括皮肤钙质沉着(Calcinosis)。雷诺氏现象(Raynaudis phenomenen)、食道受累(Esoph agectasis)、指(趾)硬皮病(Sclerodactyla)和毛细管扩张(Telangiectases)。其临床表现主要为大关节如肘、膝等关节出现皮下呈结节状的钙盐沉着。雷诺氏现象明显,严重者可引起肢端渍疡及坏死。不同程度的吞咽困难,钡剂透视可见整个食道扩张和蠕动减弱,食道下1/3处常有狭窄。毛细血管扩张多见于颜面、手足,也可以出现在口腔、鼻腔粘膜而引起口腔出血和鼻韧。本病多见于中年妇女,一般无全身症状和内脏损害,预后较好。此综合征属皮脉科范畴,较为罕见。现将我们遇见的一例报告如下: CREST syndrome is the sclerosis of the sclerosis. It includes skin calcinosis. Raynaudis phenomenen, Esoph agectasis, Sclerodactyla, and Telangiectases. The main clinical manifestations of large joints such as elbows, knees and other joints appeared subcutaneously nodular calcium sedation. Raynaud's phenomenon is obvious, severe cases can cause limb ulcers and necrosis. Different degrees of dysphagia, barium see the entire esophageal dilatation and peristalsis diminished weakened esophagus often 1/3 of the stenosis. More common in the expansion of capillaries in the face, hand and foot, can also appear in the mouth, nasal mucosa caused by oral bleeding and nose toughness. The disease more common in middle-aged women, generally no systemic symptoms and visceral damage, the prognosis is good. This syndrome belongs to the category of epidermis, is relatively rare. We now meet a case report is as follows: