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将鼻咽癌单克隆细胞株（ＣＮＥ－２Ｚ－Ｈ５）移植于裸鼠皮下，待裸鼠发生转移时，取其淋巴结和（或）肺转移灶癌细胞再次移植裸鼠皮下传代，如此用转移灶癌细胞重复传２－４代后，观察各代裸鼠的转移率和转移途径；同时观察各代癌细胞生长曲线、增殖指数及移植瘤瘤重和体积倍增时间的变化。结果显示：随着鼻咽癌转移灶癌细胞裸鼠体内的演进，各代裸鼠的转移率增高，且转移途径更为单一；各代癌细胞的增殖能力不断增强。提示：鼻咽癌细胞在裸鼠体内演进中转移能力和增殖能力均不断增强，且二者关系密切。
The nasopharyngeal carcinoma monoclonal cell line (CNE-2Z-H5) was subcutaneously transplanted into nude mice. When the nude mice had metastasis, the lymph node and / or metastatic lung cancer cells were subcutaneously transplanted subcutaneously in nude mice, After 2-4 passages, the metastatic rate and metastasis of nude mice in each generation were observed. The growth curve, proliferation index, tumor weight and volume doubling time were observed. The results showed that with the development of NPC in nude mice, the metastatic rate of each generation of nude mice increased, and the metastatic pathway was more single. The proliferation ability of cancer cells in each generation was continuously enhanced. Tip: nasopharyngeal carcinoma cells in vivo nude mice in the evolution of metastatic capacity and proliferative capacity are continuously increasing, and the two are closely related.