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片剂是一种使用最广泛的口服固体制剂,随着生物药剂学的进展,要求这类药剂在口服后能在特定的时间内达到一定的血药浓度。并减少副作用。从而达到提高疗效的目的。由于新辅料的应用,使片剂在崩解、释放、控释、胃溶、肠溶、生物利用度等方面有可能进行有效的人为控制,而这已成为提高固体制剂质量的重要途径。为了提高主药在片剂中的溶出度,除了对主药的粒子细度提出要求外,所选用的辅料对
Tablets are one of the most widely used oral solid preparations. With the development of biopharmaceuticals, these medicines are required to reach certain plasma concentrations within a specified time after oral administration. And reduce side effects. So as to achieve the purpose of improving the curative effect. Due to the application of new excipients, it is possible to effectively control the tablets in terms of disintegration, release, controlled release, gastric solution, enteric, bioavailability and the like, and this has become an important way to improve the quality of solid preparations. In order to improve the dissolution rate of the main drug in the tablet, in addition to the main drug particle size requirements, the choice of accessories pairs