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假地胆草(Pseudoelephantopus spicatus)在菲律宾常用作局部药物,治疗创伤、湿疹、蛇咬伤和用于消炎。据报道,曾从假地胆草叶中分离出5种吉马烷内酯和1种杜松烷内酯。本次从假地胆草中分离出另一种杜松烷内酯,以1D和2D NMR光谱和质谱学为基础,鉴定出该成分的结构,并对其抗微生物活性进行了检测。 干燥假地胆草叶(500g)用氯仿提取,得到粗提物,用Pb(OAc)_2水溶液使色素沉淀,然后上硅胶柱,用乙酸乙酯-石油醚洗脱,溶于乙酸乙酯的部分再上柱分
Pseudoelephantopus spicatus is commonly used as a topical medicine in the Philippines to treat wounds, eczema, snake bites, and to reduce inflammation. It has been reported that 5 kinds of jimastanolactone and 1 of jusartan lactone have been isolated from the leaves of false grass. This time, another juniolactone was isolated from F. tangense. Based on 1D and 2D NMR spectra and mass spectrometry, the structure of the component was identified and its antimicrobial activity was tested. Dry F. pseudophylla (500 g) was extracted with chloroform to give a crude extract. The pigment was precipitated with a water solution of Pb(OAc) 2 and then applied to a silica gel column eluted with ethyl acetate-petroleum ether and dissolved in ethyl acetate. Part of the column again