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以β-环糊精(β-CD)、柠檬酸钠改性Fe3O4纳米粒子、可溶性淀粉为原料,采用反相乳液聚合法制备β-CD/淀粉磁性微球,经过硝酸铈铵-硝酸引发体系在微球表面接枝N-异丙基丙烯酰胺(NIPAAm),制得具有温度、磁场双重响应性的温度敏感型β-CD/淀粉复合磁性微球。所得微球表面圆整光滑,粒径分布较窄,粒径中值d(0.5)为129.228μm,饱和磁化强度为0.654emu/g。以乙酰水杨酸为模型药物研究了微球的药物控释性能,结果表明微球在溶胀和释药性能方面均表现出明显的温度敏感性,且外加磁场对微球的药物控释效果有较大影响。
Β-CD / starch magnetic microspheres were prepared by reversed-phase emulsion polymerization using β-cyclodextrin (β-CD), sodium citrate modified Fe3O4 nanoparticles and soluble starch as raw materials. Grafting N-isopropylacrylamide (NIPAAm) onto the surface of the microspheres to prepare temperature-sensitive beta-CD / starch composite magnetic microspheres with dual responsiveness of temperature and magnetic field. The microspheres obtained were round and smooth with narrow particle size distribution. The median diameter d (0.5) was 129.228μm and the saturation magnetization was 0.654emu / g. Acetylsalicylic acid was used as a model drug to study the controlled release properties of the microspheres. The results showed that the microspheres exhibited obvious temperature sensitivity in swelling and drug release properties. The controlled release of the microspheres by the applied magnetic field Great impact.