大剂量化疗及骨髓移植早期常引起严重骨髓抑制,由此而发生的感染并发症常使治疗失败。大剂量化疗及骨髓移植后的患者运用GM—CSF/G—CSF,能明显促进骨髓造血功能的恢复,减少感染并发症发生率和严重性。化疗早期运用CSF并收集外周血造血干细胞于化疗后回输,在自体骨髓移植中亦有广泛应用价值。 High-dose chemotherapy and bone marrow transplantation often cause severe myelosuppression in the early stage, and the resulting infection complications often lead to treatment failure. High-dose chemotherapy and bone marrow transplantation in patients with GM-CSF/G-CSF, can significantly promote the recovery of bone marrow hematopoietic function, reduce the incidence and severity of infection complications. The early use of chemotherapy for CSF and the collection of peripheral blood hematopoietic stem cells for transfusion after chemotherapy have also been widely used in autologous bone marrow transplantation.