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目的 观察葡甲胺 cAMP对慢性心力衰竭 (CHF)患者的急性血液动力学效应。方法 1 0例中、重度CHF患者 ,静脉注射葡甲胺 cAMP(60mg 3～ 5min内缓慢注射 ) ,观察用药前后血流动力学参数变化。结果 用药后 1 0min ,患者心率减慢 ,平均肺动脉压 (mPAP)及肺嵌压(PCWP)下降 ,肺循环阻力 (PVR)和体循环阻力 (SVR)降低 ,心脏指数升高 ,持续作用 30min以上。结论 葡甲胺 cAMP对CHF患者具有良好的急性血液动力学效应 ,可改善心脏作功能力
Objective To investigate the acute hemodynamic effects of meglumine cAMP in patients with chronic heart failure (CHF). Methods One hundred and ten patients with severe CHF were injected intravenously with meglumine (60 mg for 3 ~ 5 min). The changes of hemodynamics before and after treatment were observed. Results At 10 minutes after treatment, the heart rate was decreased, mean pulmonary arterial pressure (mPAP) and pulmonary capillary pressure (PCWP) decreased, pulmonary resistance (PVR) and systemic resistance (SVR) decreased, and cardiac index increased for more than 30 minutes. Conclusions Meglumine cAMP has a good acute hemodynamic response to CHF and improves cardiac performance