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国外对疟疾疫苗的研究比较重视,进展很快,大致可分为两个阶段:第一阶段主要是寻找疟原虫的保护性抗原(1980—1982);第二阶段是用基因重组方法,准备大量生产疟原虫抗原,并对抗原的氨基酸序列加以分析(1983—1985)。今后即将进入人体试用阶段。我国对疟疾疫苗的研究工作,现已完成第一阶段工作,正进入第二阶段。由于疟原虫生活史中,子孢子、裂殖子和配子三个时期不在细胞内寄生,而游离在细胞外,最易受到宿主免疫反应的攻击,因此疫苗多针对这三个时期。其中子孢子疫苗的研究进展最快,裂殖子次之,
The research on malaria vaccine in foreign countries pays more attention and progresses rapidly. It can be divided into two stages: the first stage is to find the protective antigen of Plasmodium (1980-1982); the second stage is to use gene recombination method to prepare large quantities Production of Plasmodium antigen, and analysis of the amino acid sequence of the antigen (1983-1985). In the future is about to enter the human trial stage. The research work on malaria vaccine in our country has now completed the first phase of work and is entering the second phase. As the Plasmodium life cycle, sporozoites, merozoites and gametes three periods are not parasitic cells, and free in the cell, the most vulnerable to host immune response attacks, so the vaccine for the three periods. The sporozoite vaccine research progress fastest, followed by merozoites,