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本实验用模拟高海拔状态,分别在4000米、6000米和8000米高度经30分钟后,观察急性缺氧对小鼠耳廓微循环的影响,同时观察小鼠尾血流图和行为的改变。结果表明,随海拔高度上升,耳廓微循环障碍逐渐加重,主要表现为血管扩张,毛细血管数增多,血流减慢,渗出和轻度出血,其失代偿高度为6000米。尾血流量随海拔高度上升或减压时间延长逐渐减少。行为的变化过程主要表现为活动减少,静卧,紧张烦燥和对外界刺激的反应性降低。在时相上,耳廓微循变障碍与尾血流量减少和行为变化具有一致性,因而,微循环障碍可能构成急性缺氧时造成机体进一步损伤的因素之一。
In this experiment, simulate the high altitude state, respectively, at 4000 meters, 6000 meters and 8000 meters altitude 30 minutes after the observation of acute hypoxia mouse auricle microcirculation, while observing the mice tail blood flow and behavior changes . The results showed that as the altitude increased, the auricle microcirculation disturbance gradually increased, mainly as vasodilation, increased capillary number, blood flow slowed, exudation and mild bleeding, the decompensation height of 6,000 meters. Tail blood flow increased with the altitude or reduced decompression time gradually reduced. Behavioral changes in the process of performance is mainly reduced activity, lying, tension and irritability and reduce the reactivity of external stimuli. In phase, microcirculation disturbance in the auricle is consistent with decreased tail flow and behavioral changes, thus microcirculation may constitute one of the factors that cause further body damage during acute hypoxia.