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在希夫碱Cu(Ⅱ)配合物Ⅰ〔Cu(Ⅱ)双香草醛缩乙二胺〕、Ⅳ〔Cu(Ⅱ)双香草醛缩邻苯二胺〕的基础上,对配体结构进行了设计,将重原子效应、共轭效应、空间位阻效应等结构影响因素引入到SOD(超氧化物歧化酶)模拟物的结构设计中,合成了4种希夫碱类铜金属配合物,并用X射线单晶衍射法测定了配合物Ⅱ的晶体结构。运用改进的NBT还原法测定了该6种SOD模拟物的抗氧化活性,结果表明,结构改变后的SOD模拟物较原结构配合物的抗氧化活性均有明显提高且各因素影响幅度有所不同。
Based on the Schiff base Cu (Ⅱ) complex Ⅰ [Cu (Ⅱ) bis vanillin aldehyde ethylenediamine] and Ⅳ [Cu (Ⅱ) bis vanillin aldehyde o-phenylenediamine] Design, the heavy atom effect, conjugation effect, steric hindrance effect and other structural factors were introduced into the SOD (superoxide dismutase) mimic structural design, synthesis of four Schiff base copper metal complexes, and use The crystal structure of complex Ⅱ was determined by X-ray single crystal diffraction. The antioxidant activity of the six SOD mimetics was determined by the improved NBT reduction method. The results showed that the antioxidant activity of the SOD mimics after the structural modification was significantly higher than that of the original structural complexes, and the influence range of each factor was different .