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用致癌剂二甲基苯丙蒽丙酮溶液诱导４０只金黄地鼠颊囊癌过程中动态观察微血管形态、机能和血液流变状况的变化。结果表明，癌变前病变区微血管无明显改变，肿瘤出现后病变区微血管排列紊乱、扭曲、不平整、无极向，数目减少，出现瘀血和血窦，血流速度减慢，流量减小等改变。微循环障碍随肿瘤生长而加重。肿瘤形成前后血液流变状态有明显差异，与微血管变化吻合。血液瘀滞度随癌肿生长而加剧。血液流变改变主要是因肿瘤生长过程中大分子物质增加，血细胞表面负电荷减少，从而聚集性增强。实验证明，肿瘤区微循环机能和微循环障碍互为因果关系。
Dynamic changes of microvascular morphology, function and blood rheology were observed during the carcinogenesis of 40 golden hamster cheek pouch carcinomas induced by the carcinogen dimethylbenzofuran acetone. The results showed that there was no significant change in the microvessels in the precancerous lesions. After the tumor appeared, the microvessels in the diseased area were disordered, distorted, uneven and nonpolar, and the number decreased. Blood stasis and sinusoids appeared, the blood flow velocity decreased and the flow rate decreased . Microcirculation disorders increase with tumor growth. Tumor formation before and after the state of blood rheology were significantly different, consistent with microvascular changes. Blood stasis intensified with cancer growth. Hemorheological changes mainly due to the increase of macromolecules in the process of tumor growth, negative charge on the surface of blood cells decreased, and thus increased aggregation. Experiments show that the tumor area microcirculation and microcirculation dysfunction each other causal relationship.