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目的：探讨ｂｃｌ２蛋白在胃癌发生过程中的表达。方法：用免疫组化方法检测良恶性胃粘膜病变（１５例肠上皮化生，３０例不典型增生，６０例胃癌）ｂｃｌ２蛋白的表达。结果：其免疫阳性率分别为４６７％、６０％、６８％，ｂｃｌ２蛋白表达与胃癌分化程度显著相关，但与其它病理特征关系不明显。结论：ｂｃｌ２异常表达可能在胃癌形成早期即发生作用，其表达与胃癌分化程度呈反相关。
Objective: To investigate the expression of bcl2 protein in gastric carcinogenesis. Methods: The expression of bcl2 protein in benign and malignant gastric mucosal lesions (15 cases of intestinal metaplasia, 30 cases of atypical hyperplasia, and 60 cases of gastric cancer) was detected by immunohistochemistry. Results: The positive rate of immunohistochemistry was 46.7%, 60% and 68% respectively. The expression of bcl-2 protein was significantly related to the differentiation of gastric cancer, but it was not significantly related to other pathological features. Conclusion: Abnormal expression of bcl 2 may play an important role in the early stage of gastric cancer, and its expression is inversely related to the degree of differentiation of gastric cancer.