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采用放射免疫法检测了３４例细菌性脑膜炎，２６例病毒性脑炎患儿急性期、恢复期血清中肿瘤坏死因子（ＴＮＦ）的含量。结果表明：细菌性脑膜炎急性期ＴＮＦ含量与病毒性脑炎急性期和对照组比较，明显增高（Ｐ＜０．００１），恢复期则降至正常，而病毒性脑炎急性期、恢复期同对照组比较无明显变化（Ｐ＞０．０５）。同时发现ＴＮＦ含量与患儿的病情轻重及预后有关，ＴＮＦ水平越高，则病情重，预后差。说明ＴＮＦ含量的检测对鉴别细菌性脑膜炎与病毒性脑炎、判断预后，有一定的意义。
Radioimmunoassay was used to detect the levels of serum tumor necrosis factor (TNF) in 34 cases of bacterial meningitis and 26 children with viral encephalitis at acute and convalescent stages. The results showed that the content of TNF in the acute phase of bacterial meningitis was significantly higher than that in the acute phase of viral encephalitis and the control group (P <0.001), and returned to normal in the recovery phase. However, the viral encephalitis acute phase and convalescence phase Compared with the control group no significant change (P> 0.05). Also found that the level of TNF in children with the severity and prognosis, the higher the level of TNF, the serious condition, the prognosis is poor. It is of certain significance to detect the content of TNF in distinguishing bacterial meningitis from viral encephalitis and prognosis.