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近年来的研究表明,微卫星不稳定性(MI)尤其是高度微卫星不稳定性(MI-H)与许多肿瘤的发生和发展关系密切。本文就MI的发生和致瘤机制、临床病理学意义以及MI相关研究存在问题等方面的研究现状作一综述。
In recent years, studies have shown that microsatellite instability (MI), especially high degree of microsatellite instability (MI-H), is closely related to the occurrence and development of many tumors. This review summarizes the current situation of the pathogenesis of MI and its mechanism of tumorigenesis, clinicopathological significance and existing problems of MI related research.