目的：由于济南东郊历城区１９８８年１０月首次发现恙虫病临床病例而开展流行病学调查。方法：采用斑点酶标染色法（ＩＥＡ），检测患者、鼠类血清抗恙虫病立克次体（Ｒ．ｔ）；采用间接免疫荧光法（ＩＦＡ），进行血清分型；同时进行病原分离。结果：有７个乡镇发生恙虫病流行，属秋冬型；流行季节储存宿主和传播媒介以黑线姬鼠和小盾纤恙螨为主；秋冬型恙虫病立克次体属弱毒株，接种小白鼠后无规律性死亡；从３组鼠类标本接种小白鼠的组织印片分离出Ｒ．ｔ，血清抗Ｒ．ｔ阳性。结论：血清学分型属Ｇｉｌｉａｍ型；疫源地属山地丘陵型 OBJECTIVE: To carry out epidemiological investigation of the first case of tsutsugamushi disease in the city of Ji’nan, eastern suburbs in October 1988. Methods: The sera from patients and mice were detected by Dot-enzyme-labeled Staining (IEA). The indirect immunofluorescence assay (IFA) was used to detect the serotypes of serovar Typhimurium, and the pathogen was also isolated. Results: Epidemics of tsutsugamushi were found in 7 towns and townships in autumn and winter type. Seasonal seasons host and media used Apodemus agrarius and Chigger mite as chickens, while autumn and winter strains of Rickettsia tsutsugamushi were attenuated and vaccinated There was no regular death after the mice; R was isolated from the tissue print of the mice inoculated with the three groups of mice. t, serum anti- R. t positive. Conclusion: Serological typing is Giliam type; foci are mountainous hilly type