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哮喘病人患胃-食管返流(GOR)较正常人群多,统计数字为30~89%不等,一般认为约50%。胚胎期食管与支气管均由前肠分化而来,通过两者共同的自主神经支配,胃酸返流可由迷走神经介导的反射促发支气管收缩,炎症食管中的酸性物质作用于暴露的受体,然后通过迷走神经使得气管的高反应进一步增强。对于胃-食管返流与哮喘相关机制的这一假设最为广泛接受,这一机制反过来使气道对其他能引起支气管收缩的外来刺激更为敏感。在某些病人,哮喘可能是胃食管返流的病因;这种论点认为,气管受阻时,跨横膈压力上升,可将胃内容物
Asthma patients suffer from stomach-esophageal reflux (GOR) more than the normal population, the statistics for 30 to 89%, generally considered about 50%. Esophageal and bronchial stages of the embryo are differentiated from the foregut by the common autonomic control of both, gastric acid reflux induces bronchoconstriction by vagal-mediated reflexes, and acidic substances in the inflammatory esophagus act on exposed receptors and then Tracheal hyperresponsiveness is further enhanced by the vagus nerve. This assumption of the mechanism of gastro-esophageal reflux and asthma is the most widely accepted and this mechanism in turn makes the airways more susceptible to other extraneous stimuli that cause bronchoconstriction. In some patients, asthma may be the cause of gastroesophageal reflux; this argument suggests that tracheal obstruction, cross-diaphragmatic pressure rise, the stomach contents